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Big Idea 3, Investigation 7, Science Practices 1, 2, 5, 6, 7
The cell cycle has been infiltrated, controls are failing and cell division is out of control! Cell division is regulated by a complex set of cell signals. Three checkpoints in the cell cycle control whether the division process proceeds normally, halts for repairs or triggers cell death. What happens when infection by a virus or radiation causes the controls to fail? What are the consequences of uncontrolled cell division?
This Flinn Inquiry Lab Kit begins with a Baseline Activity that instructs students to compare normal karyotypes to two known cancerous karyotypes. After these karyotypes have been identified, students will evaluate and assess two unknown karyotypes. In the Opportunities for Inquiry portion of the lab, students are guided to conduct research into aneuploidy and translocation in a cancer type of their own choosing. One or more karyotypes for these other cancers can be found online. Students then prepare a mini-poster or presentation to share with their peers.
Includes detailed teacher notes, printable student handouts and sample karyotypes for eight groups of students.
HS-LS1-1. Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.
HS-LS1-2. Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.
HS-LS1-4. Use a model to illustrate the role of cellular division (mitosis) and differentiation in producing and maintaining complex organisms.
HS-LS3-2. Make and defend a claim based on evidence that inheritable genetic variations may result from (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors.